A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
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چکیده
منابع مشابه
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of disabling symptoms. Myocardin Related Transcription Factor-A (MRTF-A) is a transcriptional co-activator that is sequestered in the cytoplasm and...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0126015